The firm says demand has declined for its premium bottled ciders.
A Herefordshire-based cider company is making all bottling posts redundant.
HP Bulmer Ltd told staff at its factory in Hereford that 54 jobs would be lost from the bottling line in Plough Lane.
From March, Bulmers Original cider will be bottled at Tadcaster, in North Yorkshire, on a site run by the firm's owners Scottish & Newcastle UK (S&N).
Workers were told that some may be able to relocate to other S&N sites in the UK. About 350 people will remain employed at the Hereford plant.
The company has been based in the city since the 1930s.
It said most of the cider produced in Hereford was either packaged in cans or kegs, which would be unaffected by the changes.
A spokesman for the company said: "In response to the decline in demand for premium bottled beers and ciders, S&N UK has acted to protect its long term future by reducing its overall bottling capacity."
HP Bulmer Ltd in Hereford is not associated with Bulmers cider in The Republic of Ireland, which is owned by C&C and sold as Magners Irish Cider in the UK.