Demolition work on the site of the University of Worcester's new second campus is set to start in mid-January.
The university said it wants to use many recycled materials
Birmingham-based decommissioning specialists DSM will begin work at the derelict Worcester Royal Infirmary.
The demolition work is scheduled for completion by the summer but listed Georgian buildings will be preserved.
A square with an 800-seat amphitheatre for outside performances is planned for the new campus, which is due to be finished by 2011.
The designs also include a 400-seat performance and conference centre, accommodation for 370 students and the restoration of derelict buildings.
The new campus is set to be built in two phases with the first stage, including restoration of Georgian buildings and creation of about 200 student residences, due to be completed in September 2009.
DSM's previous contracts have included work at Newcastle United Football Club, the former BBC studios at Pebble Mill in Birmingham and Derby City Hospital.
University of Worcester Pro-Vice Chancellor (Resources), Dr Martin Doughty, said: "Our plan is to use as many recycled materials as possible in the development, to maximise the site's green credentials and minimise negative effects to the environment."