The Matthew, the replica of the ship John Cabot sailed from Bristol to Newfoundland in 1496, will visit Gloucester Docks for the first time.
The Matthew will moor at Gloucester Docks for the weekend
The square-rigged caravel is being used in sequences for a television adaptation of a Terry Pratchett comic fantasy book being filmed in the docks.
After filming she will stay on for the weekend and open to the public.
Skipper Rob Salvidge said he was excited to be bringing the tall ship to the city.
"I lived and worked in Gloucester before I embarked on a life on the ocean waves," he said.
"It's amazing now to be in charge of such an unusual vessel and visit the city with Matthew."
Matthew will travel to Sharpness from the River Avon on the morning tide of 18 September then travel to the Gloucester canal arriving in the city in late afternoon.
John Cabot, backed by King Henry VII and the wealthy merchants of Bristol, sailed north west hoping to find a new way to the riches of the Orient.
Instead of China or Japan, he discovered what he called "New Founde Landes", modern day Newfoundland, Canada.