The search is on for new talent to compete in science's equivalent of Pop Idol - FameLab.
TV science presenter Kathy Sykes is among the judges for FameLab
Judges are looking for someone who can communicate science in an exciting and entertaining way to a general audience.
The competition is the brainchild of the Cheltenham Science Festival and the final takes place at next year's event.
Candidates must work in the industry and will have three minutes to impress a panel which includes presenter of BBC TV's Rough Science show, Kathy Sykes.
Professor Sykes, a physicist at the University of Bristol, said: "We are looking for people who have scientific stars in their eyes.
"These are people who can present an entertaining, original and exciting talk that is scientifically accurate but appealing to a non-scientific audience."
There will be 12 regional heats and the overall winner will get broadcasting time on Channel 4, £2000 and a schedule of events including a show at the 2006 Cheltenham Science Festival.