A decision to axe 90 academic posts is "financial" and "strategic".
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Up to 90 academic posts are to be axed at Anglia Ruskin University, based in Essex and Cambridgeshire.
The institution, which has campuses in Chelmsford and Cambridge, confirmed staff have until the end of the day to register for voluntary redundancy.
The university expects to lose between 80 and 90 academic staff by August of this year.
A university spokesperson said the cutbacks were for "financial" and "strategic" reasons.
The university, which has 28,000 students and more than 2,300 staff, has already axed degrees in modern foreign languages, and politics.