The first flight from America into Stansted Airport since 2001 is landing on Wednesday morning.
The American airline EOS is offering a daily roundtrip first-class service aimed at business travellers.
The new airline is flying between JFK airport and the north Essex terminal at a cost of about £3000 return.
Stansted Airport had a short-lived transatlantic service four years ago with Continental which was scrapped after 9-11.
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EOS
Fare: London to JFK £3,550 return after initial offer period
Number of aircraft: One Boeing 757
Number of seats: 48
Seat size: 78in flatbed
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The founder and chief executive of Eos is Dave Spurlock, an American who was formerly director of strategy at British Airways.
Mr Spurlock believes Eos can provide a new service for the "discerning business traveller".
Another American airline - Maxjet - is preparing to start a business-class service on the same route.
Both airlines aim to launch a second daily service early in 2006, doubling their overall capacity to 300 seats.