Police in Plymouth used new powers to close one of the city's main nightclubs on Saturday night.
Up to 140 officers were involved in a raid on the Dance Academy on the city's Union Street.
It follows a five-month operation which officers say showed class A drugs are being used and dealt there.
About 200 club goers were asked to leave while evidence was gathered. A hearing on Monday will decide if the club will be closed for three months.
A 35-year-old man from Honiton was arrested on suspicion permitting the supply of a class A drug on the premises and a 33-year old man from the Whitleigh area of Plymouth was arrested on suspicion of a similar offence.
New legislation under the Anti-Social Behaviour Act has given police powers to shut down licensed premises where class A drugs are being used or supplied and serious disorder or nuisance is being caused.
Chief Supt Morris Watts, from Devon and Cornwall Police, said closure orders "were not taken lightly".
"But where there is evidence of drug use and disorder, we will deal with such premises robustly," he said.
"It is likely there will be other operations like this run across the force in the coming months if the evidence warrants it."