A Devon father is hoping to make contact with his son after seven years, through a BBC programme.
Matthew O'Reilly would be aged 37 now
Matthew O'Reilly, from Barnstaple, disappeared in January 1999, aged 29. The artist had been depressed that his paintings were not selling.
The last sighting of him was at Gordano Services on the M5 in March 2000.
Matthew's story is being told on Thursday morning on BBC One at 0915 BST as part of the programme Missing.
Matthew's father Tim leaves a note on his front door whenever he goes out in the hope that one day his son may come home.
Mr O'Reilly hopes the latest Missing series, made with the assistance of the National Missing Persons Helpline (NMPH) charity, will shed new light on his son's disappearance.
He said: "It has been so long since Matthew went missing and we miss him terribly.
"We have some very important family news concerning his mother to pass on and would dearly love to hear from Matthew.
"We love Matthew very, very much but do not wish to interfere in his life, we just want to know that he is safe and well."
Matthew, a graduate from the Bath College of Art, is a self employed abstract artist.
He is 5ft 11ins tall, well- proportioned with short dark brown hair and brown eyes.
Devon and Cornwall police say there are 42 people currently missing in the South West.