Protests have been held in Plymouth after a Kurdish woman and her two teenage daughters were taken to a detention centre near Gatwick Airport.
Ruir Thaha and her two daughters aged 14 and 15 had fled Iraq to escape persecution.
They have lived in Plymouth for the last three years.
The family have now been told by the Home Office that they will be flown to Germany, where they first tried to claim asylum.
Immigration officers called at the family's home on Thursday morning.
They have been told they will be flown to Dusseldorf on Sunday and will continue to be held at the detention centre near Gatwick Airport.
The Home Office declined to comment on individual cases, but a spokeswoman said: "If an asylum applicant has passed through a country on the way to the UK which provides an adequate level of protection, he or she should have applied there.
"An EU agreement enables us to turn around about 200 asylum seekers a month to other European countries without considering their claims ourselves."
Anti-racism charity, the Monitoring Group, has been protesting at their treatment outside the immigration offices in Plymouth.
It has taken the case to the UN High Commissioner for Refugees, saying that Ruir Thaha is too ill to leave, claiming she had attempted suicide.
John Mackenzie of the Monitoring Group, said: "We are asking for an immediate halt to these proceedings while a proper medical examination is taken."