The future of the Spondon plant is under threat
More than 450 workers at a factory in Derby face losing their jobs.
Celanese is proposing the closure of its Spondon plant, which it says has high operating costs, as part of a review into its global operations.
A consultation period involving the 460 employees and their representatives has begun, and the plan is to keep the plant open until late 2011.
Celanese makes acetate products used in filtering, film and other industrial applications.
Bob Walters from Celanese said: "Despite the best efforts of many dedicated employees and Celanese investments, the operating costs at Spondon remain the highest in Celanese Acetate.
"Moreover, shifts in geographic demand, anticipated industry consumption patterns, and the site's high costs lead us to propose the cessation of manufacturing at Spondon.
"All affected employees will be treated fairly and respectfully throughout this process."
In May 2009, Celanese said 100 jobs were threatened at the plant.
The company was set up in 1914 in order assist with the war effort.
Workers produced cellulose acetate, a material which coated aircraft to reduce the fire risk in battle.
In World War II, the factory produced acetone which was used in the ammunition manufacturing process.
Between the wars, more than 20,000 workers were employed and the plant has consistently provided jobs for hundreds of workers in Spondon and Derby.