Rifles, an air pistol and kitchen knives were handed in during the first hour of a gun and knife amnesty.
A Derby city councillor called for the amnesty after the killing of Kadeem Blackwood, the first teenage victim of a shooting in the city.
Derbyshire Police and Derby Community Safety Partnership have joined forces for the initiative.
Every gun handed in during the amnesty, which lasts until 12 July, will be made safe by armed response officers.
Sharon Squires, from the Community Safety Partnership, said: "This is the first ever gun and knife amnesty in Derby.
"It's part of a wider set of initiatives around weapons and guns in Derby. We see that one less gun or one less knife is potentially one less victim."
Chief Inspector Sunita Gamblin added: "Some gang members don't always keep hold of these sorts of weapons themselves but will ask other people who are younger or perhaps more vulnerable to look after their guns or knives.
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