The first part of a new £333m hospital in Derby is to open to patients.
The urology department, the first unit to be transferred as part of the redevelopment of Derby City General Hospital site, will open on Friday.
Health bosses have said the new hospital, which will have 35 operating theatres, will cut waiting times and allow more patients to be treated.
All facilities from Derbyshire Royal Infirmary (DRI) will be transferred to the new building by the end of 2008.
Part of the DRI's London Road site will be sold off and other parts may be used for community health facilities.
Builders have been working on the project for nearly two years.
The scheme has been funded by the private sector, with the NHS leasing the facility for 35 years.
A new mini bus service is to begin on Friday to help visitors and patients travel around the site.
Other cities hope to implement a similar strategy, with plans to virtually rebuild Leicester's hospitals and Nottingham City Hospital, as well as creating a super hospital for Peterborough.