Anti-nuclear protestors are being warned special police powers will be used to limit a rally on Monday.
Protestors also blocked the same entrance in 2003
Protestors opposed to the production of nuclear fuel rods for submarines are expected to try to blockade Rolls-Royce's Raynesway plant in Derby.
A public order act allows police to limit gatherings to 50 people.
Trident Ploughshares organiser Emma Bateman said protestors are coming from all over the country, including some from Nottingham, Scotland and London.
Police say the law aims to prevent public disorder and property damage.
But Ms Bateman said: "The government is not happy about people protesting - it is not the most democratic we have ever had - especially about the issues of nuclear weapons."
Assistant Chief Constable Mick Creedon said: "We hope that people will abide by the law and enjoy the opportunity of voicing their opinions in safety.
"But if people seek to flout the law then we will not hesitate to make arrests."
Seven people were arrested during a demonstration at the same site in February 2003, but later released without charge.
Motorists travelling in the Raynesway area on Monday are being warned of possible disruption as a result of the planned action.