Falling from a height remains one of the main causes of injury
Nearly 1,400 people were killed or injured in work-related incidents across Cumbria last year, according to the Health and Safety Executive (HSE).
The 2007/2008 toll of 1,386, which includes three deaths, is an increase of 161 on the previous 12 months.
The figures prompted a call to the county's employers to make their workplaces safer in 2009.
Carlisle saw the highest numbers of incidents, with two fatalities and 358 workplace injuries.
David Sowerby, the HSE's North West operations manager, said: "Behind these statistics are cases of real suffering and, for some, hardship through loss of income.
"We are asking that businesses take practical action to manage the risks people face in their day-to-day work."
Across the North West, 19,135 people suffered workplace incidents during 2007/08, of which 28 were fatal.
Mr Sowerby added: "Again, our inspectors have found that falling from height and being struck by falling or moving objects were among the chief causes of death and injury.
"If workplaces could eliminate these factors, both of them avoidable, these startling figures would be hugely reduced."
The HSE has urged better use of risk assessments and improved training for staff.