A union is holding talks with hospital bosses after it was notified 99 jobs could go in Coventry and Warwickshire.
Amicus, the union for skilled and technical workers, is meeting with Coventry's Walsgrave Hospital after it was notified about the losses.
The union says debts run up by the four primary care trusts in the area could lead to mergers and more job losses.
A spokeswoman for Walsgrave Hospital said efforts were being made to redeploy affected staff.
She added the hospital was legally obliged to notify the unions of potential job cuts but said there were no official redundancies at this stage.
The cuts come as Walsgrave Hospital gets ready to move to a new super-hospital site in 2008 or 2009.
An Amicus spokesman said the union feared a further 200 jobs could go if primary care and community trusts in Coventry and Warwickshire merged.
All four trusts - North Warwickshire, South Warwickshire, Coventry and Coventry and South Warwickshire Mental Health Trust - are under pressure to make savings because of debts.
Amicus spokesman Bob Storry said: "We know of the 99 posts that are to be cut from Walsgrave Hospital and we fear hundreds more are at risk from Walsgrave and other hospitals in the area as a result of the mergers.
"These will have serious repercussions for the provision of acute services further exacerbated by reduction in staffing of frontline medical staff which are obviously things we will fight."