A train will leave Cornwall on Tuesday as part of celebrations to mark the 200th anniversary of the birth of the engineer, Isambard Kingdom Brunel.
The bridge was restored to Brunel's original design in 2003
The Penzance to Bristol train will be decorated with a picture-livery showing scenes of Brunel's rail achievements.
Wessex Trains says Brunel is an icon and as big an inspiration today as he was 200 years ago.
The train leaves at noon and will stop for a photo call at Brunel's Royal Albert Bridge over the River Tamar.
The Royal Albert Bridge was designed by Brunel for the Cornwall Railway Company. It cost £225,000 and was officially opened in 1859 by Prince Albert.
The bridge is known as the "Gateway to Cornwall" and is considered by many to be one of Brunel's most outstanding works.
Isambard Kingdom Brunel died four months after the Royal Albert Bridge was opened. He was 53-years-old.
In 2003, £2m was spent on essential work to restore the historic bridge to Brunel's original design.
When the train pulls into Bristol Temple Meads station, there will be a special reception where the train will be officially named Isambard Kingdom Brunel.