Up to 40 firefighters and six appliances were battling a fire at the Tothill Community centre in Plymouth on Wednesday night.
Fire officers said when they arrived the building in Knighton Road was well alight and local residents had earlier reported smoke drifting into homes.
They said the building was thought to be empty at the time and there had been no reports of any casualties.
Devon Fire and Rescue Service said the cause of the fire is not yet known.
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