Up to 350 finance jobs will be lost in Peterborough when a wealth management company relocates.
Barclays Wealth has announced it is moving its operation based at Eagle Court, Lynch Wood, out of the city.
The firm, part of the Barclays Bank group, said it had embarked on the move because of its expanding business.
About 200 support jobs will relocate to Glasgow while 150 staff will get the chance to transfer to the Bank of New York Mellon in London.
Barclays Wealth said staff who did not wish to relocate would be given a support package.
The changes will be phased in over 15 months and the business will not leave Eagle Court until the end of 2008.