The hospital will bring clinical staff and specialities under one roof
A contract which will lead to work starting on Bristol's new £430m super-hospital has been signed.
The agreement between North Bristol NHS Trust and Carillion was the final stage in the approvals process for the new hospital, to be built at Southmead.
The hospital will have 2,700 parking spaces, and 75% of beds will be in single en-suite rooms.
The project brings together services currently provided at Southmead and Frenchay hospitals.
It is due to be completed in 2014.
The trust has said the new hospital will replace some of the most outdated hospital buildings in the country with "state-of-the-art, patient-centred designs that will offer enormous benefits for years to come".
Medical director Dr Chris Burton said: "For the first time, our clinical staff and specialities will be under one roof.
"Getting an expert opinion and speed of diagnosis will be significantly improved for our patients because our clinical staff will be in one place."
He added: "The hospital has been designed so that critical services such as the emergency department, imaging, intensive care wards and theatres are very close to one another."
The hospital is being funded by a private finance initiative.
John McDonough, chief executive of the construction company Carillion, said: "Achieving financial close only two months after being appointed as the preferred bidder for this project reflects the close working relationship that we have established with the North Bristol NHS Trust."