The second academy in Bristol was officially opened by the Prime Minister on Thursday.
Bristol Brunel Academy has been rebuilt under the Rebuilding Schools for the Future programme, funded through the Private Finance Initiative.
About 1,000 pupils will move into the school, which replaces the old Speedwell Technology College.
It will be run in a trust partnership arrangement with John Cabot City Technology College.
The college will also become an academy, specialising in maths, science, technology and design, arts and the media.
Bristol's first academy, the City Academy, opened in 2003 and has more than 1,100 pupils aged between 11 and 18.
The academy replaces Speedwell Technology College
The Building Schools for the Future programme aims to rebuild or redevelop all secondary schools in England in the coming years.
Speedwell was in the first wave to be developed in Bristol, as were Hartcliffe, Whitefield, Fishponds and Brislington.
Four more schools in the city are also hoping to be redeveloped under the scheme: Ashton Park, Cotham, St Bede's, St Bernadette's and St Mary Redcliffe and Temple.