The only day centre for the homeless in a Berkshire town is to close unless it can raise £160,000 by August.
Slough Homeless Our Concern (SHOC) provides housing and drugs advice, meals, showers and laundry facilities for 300 homeless people.
But after a Lottery grant ran out in October 2004, the centre has survived on one-off donations alone.
If management fails to find funding for next year by an end of August deadline, the centre must close its doors.
The team has applied to Slough Borough Council, charitable funds and local business, so far without success.
They have also approached local supermarkets to donate food.
Mandy McGuire, project manager, told BBC News: "We are the only day centre in 20-mile radius, with the nearest in Reading and London. If we close down there will be big void."
The centre on Burlington Avenue employs four full-time and two part-time staff, plus a team of volunteers and last year helped find homes for 102 people.