There were long delays on public transport across the region
Heavy snow and freezing temperatures have caused disruption across North West England and people are being warned the difficulties will continue.
Temperatures are expected to drop as low as -6C overnight. Forecasters have warned people of icy roads and pavements in the morning.
Public transport bosses advised passengers of limited services on Tuesday night and Wednesday morning.
Hundreds of schools across the region will be closed on Wednesday.
Salford and Warrington councils have announced all schools will be closed for the day.
Details of individual school closures in other areas are on the BBC's Local websites and will be broadcast on local BBC radio stations.
BBC weather presenter Dianne Oxberry warned "there is no thaw in sight." She said snowfall was expected to ease overnight but lying snow would turn to ice.
Police have advised motorists to only travel if it is absolutely necessary. They also called on people to only dial 999 in a genuine emergency.
The North West Ambulance Service declared a "major incident."
The service's deputy chief executive Bob Williams said: "We are having to stringently prioritise all of our 999 calls and despatch our resources to life-threatening cases only.
"We would like to stress the urgency for people to stay indoors unless it is absolutely necessary."
Manchester, Liverpool and Blackpool airports were disrupted
He advised people in need of medical advice to contact NHS Direct.
A lorry driver was killed on the M60 at Stockport in one of a multitude of crashes on motorways which police dealt with across Manchester, Lancashire and Merseyside.
The M6 was closed between junctions 22 and 23, Winwick and Haydock, after a vehicle fire on the motorway on Monday afternoon.
The southbound carriageway re-opened at 1840 GMT. One lane of the northbound carriageway also re-opened. A Highways Agency spokesman said the incident was not connected to the weather.
Most bus services in Liverpool and Manchester were cancelled.
The Metrolink in Manchester suspended services on the Eccles line for most of Monday.
In Liverpool, Merseylink was also suspended.
There were runway closures at Manchester, Liverpool John Lennon and Blackpool airports. Travellers are advised to check with their airline before going to airports.