Fresh appeals to find a missing make-up artist from Sussex have been made five weeks after she was reported missing.
Diane Chenery-Wickens has not been seen since 24 January
Police said Diane Chenery-Wickens's mobile phone appeared not to have been used, and her bank accounts had not been touched.
Det Ch Insp Steve Johns said none of the 48-year-old woman's family or friends had heard from her and this was "totally out of character".
Her brother, Russell, said the family was "distraught".
He said: "It is now five weeks since Diane was last seen and all her family and many friends are distraught that there is still no news.
"We miss her so much.
"The emotional toll this is taking on our parents is heartbreaking and with Mothers' Day on Sunday it will be even worse, since she always made such a big effort on this day."
He said his sister always spent the day with their parents, and this year he and his sister Caroline would be with them to provide support.
Mrs Chenery-Wickens, from Duddleswell, was reported missing on 24 January.
Officers have searched her home, surrounding land, and parts of the Ashdown Forest, in a bid to find her.
Searches in the Ashdown Forest are continuing as a result of information received, Mr Johns said.
Her mobile, a black Motorola K1 handset, has not been recovered but "there does not appear to have been any movement on her phone", Mr Johns added.
"After making many inquiries, I am now turning to the public to ask for their help in locating it."