Fund-raiser Jane Tomlinson's husband and the NHS trust that treated her have called for a review of the availability of advanced trial drugs.
Mike Tomlinson said the call was at the request of Jane
Mrs Tomlinson's husband Mike said she found it "distressing" that she could not get access to Lapatinib, when it was available elsewhere in the UK.
She had to make a 150-mile round trip to Nottingham to get the drug.
Along with the Leeds Teaching Hospitals NHS Trust, he has asked the government to stop it happening to other patients.
Mrs Tomlinson died in September, aged 43, after a seven-year cancer battle.
While terminally ill, she raised more than £1.75 million for charity by running in three London Marathons, several triathlons and The Great North Run.
Mr Tomlinson said his wife's medical team in Leeds decided Lapatinib was her best option. It costs £6,700 per patient, per year.
However, Leeds Teaching Hospitals NHS Trust had taken the decision not to participate in a GlaxoSmithKline-sponsored access study of the treatment.
He said: "Clearly it was quite distressing for Jane to find that she would no longer be able to have the treatment that everyone thought would be most suitable for her.
"It caused a lot of distress to her and a lot of upset."
Mr Tomlinson said further approaches were made to the drug company itself and to the NHS in Nottingham, where she was eventually accepted on to the trial in April.
However, he said the delay in getting on to the trial in Nottingham severely affected her health.
"There was no doubt in our minds that delay and inability to get treatment had a long-term impact on Jane's health at that time," he said.
"This is the National Health Service. Potential life expectancy should not depend on the location where the person resides.
"She was extremely cross that there were inconsistencies across the health service which allowed some patients treatment and some patients not treatment."
Mr Tomlinson said his wife had asked him to speak out after her death.
Mr Tomlinson said making his wife travel to Nottingham for treatment was "inhumane" and "caused unnecessary aggravation to Jane at a time when she was at her most vulnerable".
He said: "Jane has been fundamentally let down by an unjust system. She has received many tributes over the last month. The most fitting would be the resolving of this issue."
Dr Phil Ayres, deputy medical director of the Leeds Teaching Hospitals NHS Trust, said: "We were deeply disappointed not to be able to offer Jane the treatment she and her consultant wanted.
"We support Jane and Mike's views that we need a debate about access to drugs that have not yet been licensed or nationally approved.
"It is currently a difficult and uncertain process to make investigational drugs appropriately available."