Researchers are looking for 300 volunteers to donate DNA to trace the ancestors of modern-day East Anglians.
Waves of invaders including the Romans will have had an influence
The team at the University of East Anglia wants volunteers who were born in the same place as their parents and four grandparents.
As part of the People of the British Isles project they want to trace the influence of invaders from the Celts and Romans to the Angles and Saxons.
Volunteers from Norfolk or Suffolk will be asked to give a small blood sample.
The DNA will be extracted from the sample and used by geneticists to build the Norfolk and Suffolk part of the map.
The only criteria are that volunteers must be over 18 and born in the same part of East Anglia as their parents and all four of their grandparents.
Researchers at the university's School of Medicine hope a genetic map of the UK will improve understanding the causes and prevalence of inherited diseases such as cancer and heart disease.