The region's train operator One plans to introduce regular direct train services between Peterborough and London from 12 December.
The Peterborough to London services will call at 10 locations in Cambridgeshire, Suffolk and Essex.
The new timetable also includes new direct services between Lowestoft and London and Harwich and London.
A One spokesman said the new timetable would help boost the economy and develop tourism.
Improved service
One managing director, Tim Clarke, said: "The new December timetable will deliver a major improvement for passengers.
"Many key stakeholders have supported our plans in helping boost economic activity and develop tourism through improvements to the rail network."
The Peterborough to London services will call at: Whittlesea, March, Ely, Bury St Edmunds, Stowmarket, Ipswich, Colchester, Witham, Chelmsford and Shenfield.
The journey time is expected to be just under 3 hours.
A new hourly service on the Ipswich to Cambridge route is also planned.