Marine, offshore and engineering industries in the north-east of England could benefit from major new markets opening up across the country.
The nuclear industry produces tonnes of spent waste
The government announced plans last year to start a decommissioning programme of ageing nuclear reactors.
Regional development agency One NorthEast is working to help local firms identify market opportunities.
It is joining forces with the British Nuclear Energy Society (BNES) on Monday to promote potential business.
The two organisations will host an event at Newcastle Civic Centre to examine the future of the industry.
The BNES, which brings together scientists and engineers to exchange best practice, is also launching a new North East branch.
The safe clean-up of more than 22 civil nuclear sites across the UK could be worth £48bn over the next 50 years and One NorthEast says the region's track record in offshore marine and chemicals means it is well placed to benefit.
David Allison, One NorthEast director of business and industry, said: "North East firms have shown that they have the ability to successfully execute multi-partner contracts and effectively deliver projects.
"It is our job to help the firms access these markets and prepare them with any additional skills or learning they may need."