The Highways Agency said 74 sets of road works on England's major routes would be completed by Easter, with work on a further 60 suspended over the weekend.
However, restrictions remain at 40 locations, including a section of the M25 around Maple Cross in Hertfordshire and a stretch of the M4 near Maidenhead in Berkshire.
Network Rail engineering work will result in longer journey times for some train passengers.
There will be reduced services on both the West and East Coast main lines, with rail-replacement buses in some areas.
Some First Great Western and South West Trains services are also affected by works, with buses replacing trains on some routes.
Abta, which represents UK travel agents, says a million people will fly from London airports this weekend, along with 155,000 from Scotland and 141,000 from Manchester.
Spain, Tenerife, the Egyptian resort of Sharm el Sheikh, Tunisia, Turkey, Florida and the Dominican Republic are among the top destinations for holidaymakers.
Thursday afternoon saw heavy traffic around Manchester and Birmingham as people left work early to get away for the Easter break.
The southbound M6 was shut close to the M1 junction in Warwickshire after a serious crash in the evening rush-hour, which left two people seriously injured.
Throughout the week, up to 100,000 people have been affected by wintry weather. Some 10,000 homes in Northern Ireland and 400 in Scotland still remain without power, after snow and ice on cables brought down power lines.
Blizzard conditions had continued into Thursday morning, when 107 people were stuck aboard Wednesday's 1611 Glasgow to Inverness train for over seven hours.
It became stranded north of Aviemore between Carrbridge and Slochd, 20 miles south of Inverness. Passengers eventually reached Inverness at about 0315 BST after two rescue trains were deployed.
Natasha Paton died in a coach crash near Biggar in South Lanarkshire
On Wednesday, Natasha Paton, 17, from Cleghorn, was killed when a school coach crashed on the A73 at Wiston, South Lanarkshire.
Natasha's parents issued a statement in which they said they were devastated at the loss of their "beloved daughter", adding that she would "be greatly missed by all who knew her".
The school coach had been carrying 39 students from Lanark Grammar School, five members of staff and a driver when it left the road and ended up on its side just after 0600 BST.
NHS Lanarkshire said 44 people in total had received hospital treatment following the crash.
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