The message across many front pages is clear - 'the drugs don't work'.
The Guardian leads with the claim that scientists say Prozac, used by 40m people, is ineffective.
One of them told the paper: "There seems little reason to prescribe anti-depressant medication to any but the most severely depressed patient."
The Times says that millions of people on common anti-depressants such as Prozac and Seroxat might as well take a dummy pill.
Other front and inside pages concentrate on what the Telegraph calls one of Britain's most notorious unsolved crimes.
The conviction of Levi Bellfield for two murders means the papers can report he is the main suspect in the killing of Milly Dowler, 13, in 2002.
The Sun carries a Dowler Dossier: 10 pieces of circumstantial evidence that it says link Bellfield to the crime.
It says he lived just a hundred yards from where she was last seen.
The Daily Mail keeps up the pressure on beleaguered Speaker of the House of Commons Michael Martin.
It says he faced an extraordinary attack inside the Commons on Monday.
The Daily Mirror describes how he withstood it, telling MPs to stand up and say if they wanted him to step down from the post.
The Guardian's sketch writer Simon Hoggart was in the chamber, and says the only thing MPs unite in is a hatred of the media.
The Financial Times poses the "eternal question" - should universities exist for economic reasons or to increase the sum of civilisation?
It has seen plans which it says would allow employers to design and fund degree courses with universities.
The Daily Express is more concerned about the 11m people who cannot afford a dentist.
It reports that more than half of adults now have teeth missing because check-ups are too expensive.