The Prince's Trust charity is to launch its first advertising and public fund-raising drive to mark its 30th anniversary and highlight its work.
Charles set up the charity with his Royal Navy severance pay
Running from mid April, the campaign will feature radio and print adverts and will culminate in a TV show in May.
The charity for disadvantaged young people founded by Prince Charles has helped more than half a million people.
The Trust's Martina Milburn said the charity aims to change many youngsters' belief that "they matter to no-one".
About 100 young people aged 14 to 30 benefit from the charity, which offers practical support including training, mentoring and financial assistance.
PRINCE'S TRUST FACTS
The charity was set up with £7,400 in severance pay Charles received when he left the Royal Navy
The Trust has an annual turnover of nearly £50m and 12,000 volunteers and staff
When the charity began, 21 pilot projects were set up around the country
The Prince's Trust focuses on those who have struggled at school, been in care, or in trouble with the law, or are long-term unemployed.
Two months ago, Prince Charles said many youngsters who were labelled "youths, hoodies or thugs" were not nameless and faceless, but individuals and that he wanted his Trust to "invest in their futures".
The campaign's slogans will ask "how can a young offender avoid becoming an old offender?" and "from care home, to care home, to care home, to nobody cares?"
The adverts will go on to explain how the Trust can change young lives and create positive outcomes.
The TV show, to be aired on 20 May, will feature comedy, sport and live highlights from a music concert at the Tower of London which will feature performances from UK and international stars.
Prince Charles and his sons Princes William and Harry will give their first ever joint television interview to mark the anniversary.
The pre-recorded chat with TV hosts Ant and Dec, who are ambassadors for the charity, will be screened during the show.
Looking forward to the concert in May, Prince William said: "Everyone faces problems from time to time, but too many young people have lost all hope for the future.
"The Prince's Trust gives practical support to help these people get back on their feet.
"That's why I'm looking forward so much to this great evening."
A survey commissioned by the charity to coincide with the fundraising drive found two-thirds of the UK underestimates the number of disadvantaged young people in need of support.
The findings, based on the responses of 1,278 people, revealed that while 80% of the population believe that more should be done to give young people a second chance, as many as a quarter do not know how to help them.
The survey found the support of family and friends - 38% - is believed to be the most important factor for a young person to succeed in life, ahead of motivation - 21% - or talent - 2%.
Supporters can register for a fundraising pack through the website www.pt30.org.uk or by calling 08456 56 22 22.