Peter Eatherley, the centre's development manager, said: "This project will make a real contribution to the literacy and educational achievements of the children of east London."
The centre's aim is to "expand the horizons" of local children through stimulating and educational hand-on exhibits, workshops and play projects.
Chris Smith: "Significant landmark"
Mr Smith said the award was a "significant landmark" for the Charities Board.
He said: "The government wants to see the lottery offering something for everyone and I congratulate the Charities Board on its efforts to ensure that money goes across the country to organisations in greatest need."
Here are some of the National Lottery's headline-making grants on the way to hitting £1bn:
In November National Lottery charity chiefs handed over £200,000 to a nationwide gay helpline - it prompted criticism as the Board was accused of favouring gay and minority groups.
Also in November the south Yorkshire town of Barnsley was earmarked for National Lottery cash - it was the first time an entire town had been targeted a
bid to improve a low uptake of grants in coalfield communities.
In July 1998 the Cusichaca Trust, based in the village of Belbroughton in Worcestershire, was awarded £300,000 to breed giant guinea-pigs in Peru.
National Lottery prize money not claimed before the 180-day deadline all goes to the Good Cause Fund - by June 1998 the fund had topped the £150m mark.
In March 1998 the National Lottery Charities Board gave £220,000 to a farm supplying pigs with underfloor heating, snout-operated showers and snacks in the shape of toys to prevent them becoming board. The 100% grant was awarded to the Whirlow Farm Trust in Sheffield.
A Muslim community centre granted £375,000 of National Lottery money insisted on giving the money back - saying their holy book, the Koran, stated it should not benefit from gambling.