Natallie Evans and Lorraine Hadley have lost a case challenging a law which says both parties must consent to the storage and use of embryos at every stage of the IVF process.
The women have been refused the right to appeal, but could take their case to the Court of Appeal or on to the European Courts.
The High court ruled the embryos of both women should be destroyed - but that will not happen until the conclusion of the appeals process.
The 1990 Human Fertilisation and Embryology Act says cannot be implanted in women unless both partners involved in their creation consent to the procedure.
You put your questions to Professor Michael Freeman, law expert and medical ethicist..
Do you think agree with the High court decision? Do you think it would have been dangerous step to change the rules on consent?