Pakistani Prime Minister Zafarullah Khan Jamali, who has resigned, is a veteran politician from an influential political family.
Jamali's resignation ends weeks of speculation
He is known as a moderate, middle-of-the-road leader - characteristics which observers say may have ultimately cost him his job.
There was speculation that relations between President Pervez Musharraf and the prime minister deteriorated over Mr Jamali's alleged failure to endorse Mr Musharraf's policies fully, or deal effectively with the opposition in parliament.
Mr Jamali was among several senior members of former Prime Minister Nawaz Sharif's Pakistan Muslim League party who defected after the military coup that brought General Musharraf to power in 1999.
They formed their own faction, the PML-Q, which won the most seats in general elections in October 2002.
While Mr Jamali has asserted himself on occasions, critics said he was never likely to challenge Mr Musharraf directly.
Born in 1944, Zafarullah Jamali was the country's first prime minister from the south-western province of Balochistan, a large but sparsely populated territory which borders Afghanistan.
He began his political life as a member of the Pakistan People's Party (PPP), which he joined in the 1970s, and was regularly elected to the national and provincial parliaments.
He featured in various national Cabinets - first under the left-leaning Zulfiqar Ali Bhutto in the 1970s, then under military dictator Zia ul Haq in the 1980s.
He also served in the civilian government led by Mohammad Khan Junejo later in that decade.
In 1988, he became acting chief minister of Balochistan, a post to which he was reappointed following the dismissal of the Benazir Bhutto government in 1996.
In elections the following year, he became a senator in Islamabad.
Married with three sons and a daughter, Mr Jamali comes from a landowning family which has played an active role in Pakistani politics for over 50 years.
He was born in the village of Rowjhan, and attended the prestigious Royal College at Murree and Aitchison College in Lahore before gaining a Masters degree at Punjab University.
He speaks English well and is also fluent in the main local languages including Urdu, Punjabi, Sindhi, Pashto and Balochi.