Jules Verne's re-entry mass is about six tonnes lighter than at launch
Europe's biggest, most sophisticated spaceship is about to bring its six-month mission to an end by plunging into the Pacific in a ball of flames.
The "Jules Verne" freighter undocked from the space station three weeks ago packed with rubbish and will take its unwanted cargo into a destructive dive.
Most of the vehicle is expected to burn up in the atmosphere; only fragments will make it down to the ocean water.
Two engine firings should bring the ship out of the sky on Monday.
Events will be overseen from the European Space Agency's (Esa) freighter control centre in Toulouse, France.
Mike Steinkopf, the mission director for re-entry, says a "safety zone" has been drawn in the south Pacific some 2,700km long by 200km wide.
We will see what appears to be a very bright meteor
Jason Hatton Esa-Nasa re-entry observing team
"We issue a notification to the air traffic and maritime authorities to make sure there are no planes or boats going through that zone during our re-entry time," he told BBC News.
Astronauts on the overflying International Space Station (ISS) and scientists in two chase planes will take pictures as the disintegrating mass of metal streaks through the morning Pacific darkness.
"Visually, we will see what appears to be a very bright meteor," explained Jason Hatton from the chase team set by Esa and the US space agency (Nasa). "It will start as a point of light with a trail, and then as it comes apart, we will see fragments."
Jules Verne - also known by the generic name Automated Transfer Vehicle (ATV) - cost about 1.3bn euros to develop.
Although Esa has produced many complex scientific satellites, none match the scale of the freighter.
After launch, the space truck can work out where it needs to go in space, and then makes a fully automatic docking once it arrives at its destination.
JULES VERNE - THE FIRSTS
The ATV is the first completely automated rendezvous and docking ship to go to the ISS
The ATV is the largest and most powerful space tug going to the ISS over its mission life
It provides the largest refuelling and waste elimination capability for the space station
It is the only vehicle on the current timeline able to de-orbit the ISS when it is retired
Approximately two hours later, the engines will be fired again, this time for some 15 minutes. This should take the ATV on its final trajectory and a steep dive towards the Pacific.
The freighter is expected to be moving at some 7.6km/s as it meets significant atmosphere at 120km. As the plunge continues and temperatures rise, Jules Verne will be torn part.
"We expect the solar panels to break just two-and-a-half-minutes after the entry into the atmosphere; and then we will have fragmentation of the docking adaptor, protective shields and other structural elements," explained Mr Steinkopf.
Animation of Jules Verne's final voyage
"Nevertheless, statistically speaking, there will be about 30% of the overall vehicle that may reach the ocean, but only in bits and pieces."
The final moments will be witnessed in the Pacific by two chase planes. The jets, a Gulfstream-V and a DC8, will carry an observation team equipped with a range of spectroscopic imagers and conventional video and stills cameras.
The team wants to establish in detail how the different components of Jules Verne, such as its fuel tanks, come apart.
The information will inform the computer models used by space agencies to plan the safe re-entries of future spacecraft.
"We expect to see signatures associated with the fuel in the wake of the vehicle because you have this trail behind it," Mr Hatton told BBC News from the team's campaign base in Tahiti.
"That's where the spectroscopy comes in. You have a range of different spectrographs all the way from the near-ultraviolet, through the visible to the near-infra-red. In the different colours, we'll probably see what materials are being released from the vehicle, maybe what some of the fragments are - aluminium, for example."
Under the agreement Esa has with its international partners, at least four more ATVs will be flown to the space station in the coming years. The next is due to launch in 2010.
And, ultimately, it is likely that an ATV will be tasked with destroying the space station when the partners have decided the platform is beyond servicing, perhaps towards the end of the next decade.
A freighter will be commanded to drive the whole structure into a similar region of the south Pacific.
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