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BBC Science's Helen Sewell
"Ebola is one of the most virulent diseases known"
 real 28k

Thursday, 2 March, 2000, 19:26 GMT
Ebola cure possible
Ebola killed 245 people in Zaire in 1995
Ebola killed 245 people in Zaire in 1995
Ebola, one of the most terrifying diseases in the world, could be treatable according to a new study.

The research, done on mice in the US, even suggests that an effective vaccine could be developed in the future.

Ebola viruses cause catastrophic internal bleeding in infected humans. The disease is nearly always fatal and no vaccines or treatments currently exist.

Several lethal strains of the virus
Several lethal strains
However, the scientific team, led by Mary Kate Hart at the US Army Medical Research Institute of Infectious Diseases in Maryland, has discovered a promising approach.

They managed to produce antibodies to the virus in laboratory mice. These antibodies were then removed and replicated.

A second set of mice was injected with the antibodies, both before and after being injected with Ebola - many of them survived, despite receiving 300 times the lethal dose.

The antibodies were administered a day before or after infection, which normally kills within a week. Most of the mice lived for at least 28 days.

New hope

There are several lethal strains of the Ebola virus but the disabling antibodies attach to a part of the virus common to all of them.

Previous studies had suggested that antibodies did not help protect from Ebola, but this new work shows that there is hope.

"These results suggest that it is possible to elicit by vaccination, or produce for therapeutic use, antibodies protective against all Ebola viruses that are pathogenic for humans," the team conclude, in the journal Science.

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See also:

16 Aug 99 |  Medical notes
Ebola and other tropical viruses
05 Jan 00 |  Health
Bug battle enters new century
15 Oct 99 |  Health
Clues on Ebola's origin
05 Aug 99 |  Health
Ebola cure hope
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