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Thursday, 18 April, 2002, 04:10 GMT 05:10 UK
Parkinson's brain renewal advance
Pallab Ghosh and Roger Nelson, BBC
Roger Nelson (right) has shown dramatic improvements
test hello test
By Pallab Ghosh
BBC science correspondent
Doctors in Bristol, UK, have developed an experimental treatment which, they suspect, has regenerated the brains of five patients with Parkinson's disease.

I burst out laughing, which I hadn't been able to do for several years

Roger Nelson
One patient has learned to laugh again and has regained his sense of smell.

The doctors say it is too soon to tell whether the treatment is long lasting or could be used on all sufferers of Parkinson's.

But they have been astonished at how effective the treatment has been so far.

The treatment involves putting a drug called GDNF (Glial cell line-Derived Neurotrophic Factor) into a mechanical pump, two of which feed it to the most damaged parts of the brain.

Consultant neurosurgeon Stephen Gill
Mr Gill and colleagues were surprised at the results
"We can deliver a drug very precisely to areas in the brain in the concentrations that we need to cause recovery and we can control that very precisely," said Stephen Gill, consultant neurosurgeon at Frenchay Hospital.

He said he and his colleagues were very surprised at the effects of the treatment.

Rapid progress

"We thought that this drug would take some months or years to be effective [but] we found that really within a month or two patients were noticing significant changes."

Pump graphic, BBC
Two pumps in Mr Nelson's body feed the drug to his brain
Patients with Parkinson's disease lose their sense of smell and taste but this recovered very early, he said.

Roger Nelson, who took part in the Bristol trial, told the BBC what the treatment had meant for him.

"Being able to talk better, walk better, smile and also laugh again.

"My wife passed a slightly risque comment just after I got home from hospital and I burst out laughing, which I hadn't been able to do for several years," he said.

Further research

Nik Patel, consultant neurosurgeon at Frenchay Hospital, counsels caution.

Brain image
The treatment targets degenerated brain areas
"I think we're a way from a possible cure yet and we have many hurdles to cross and many theories to prove but that remains a possibility.

"We have to prove that this drug is continually effective, safe and does reverse the disease, and in time we may see the results on a Pet (Positron Emission Tomography) scan confirming these cells have re-grown," he told the BBC.

The new treatment has worked well on five people - but that is too few to know for sure whether it is an effective therapy. But the results so far are promising and it has given Roger a new lease of life.

If you are a sufferer of the disease or have experience of Parkinson's e-mail us your thoughts on the new treatment using the form below.

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Disclaimer: The BBC will put up as many of your comments as possible but we cannot guarantee that all e-mails will be published. The BBC reserves the right to edit comments that are published.
The BBC's Pallab Ghosh
"Doctors will have to test the drug more thoroughly before making it more widely available"
Linda Kelly, Parkinson's Disease Society
"Maybe we can take a step forward"
Parkinson's treatment patient Roger Nelson
"I got my sense of smell back"
See also:

08 Jan 02 | Health
Parkinson's stem cell advance
26 Nov 98 | Medical notes
Parkinson's Disease
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