The Pentagon says that more than 10,000 US military personnel have been wounded in Iraq since the conflict began in March 2003.
An attack on a US military mess in Mosul left many dead and wounded
Newly published figures show that more than 5,000 of the wounded have been unable to return to duty.
Many have been left with serious injuries such as lost limbs and sight,
mostly as a result of the blast effects of roadside bombs.
More than 1,300 US troops have been killed.
The latest figures underline that an equally telling price is being paid in the number of US soldiers being wounded there, says the BBC's Pentagon correspondent Nick Childs.
Advances in military medicine and body armour mean that many have survived wounds that they would not have done in previous conflicts.
In Iraq on Wednesday, a car bomb killed two Iraqi civilians and wounded 10 others in Baghdad.
Police say the bomb exploded near a petrol station in the western district of Amiriyah.
The explosion came a day after gunmen assassinated the governor of Baghdad province, and in a separate attack killed at least 10 people outside the headquarters of the Iraqi National Guard.