The Red Cross and United Nations are appealing for $73m to help the people of the Iranian quake-hit city of Bam over the next three months.
Bam's residents will need aid for years to come
The money will be spent on medical care and rebuilding the city's infrastructure and farms.
The World Health Organisation says in the longer term $30m will be needed to restore the city's health service.
Nearly all medical facilities were destroyed in the earthquake which killed some 30,000 people.
Half of all Bam's health workers were killed in the tremor.
A priority now is mental health, says the WHO, as many survivors are bereaved and traumatised.
The WHO alone has appealed for $4m for immediate medical relief.
"The health needs now are ones of normalising the systems, of finding all the family members, of helping them through a very difficult period, and then getting on with the business of reconstruction," said Dr David Hayman, a specialist in communicable diseases with the WHO.
Donors are set to meet in Geneva on Friday to discuss the appeal.
Media attention was focused on Bam on Thursday after a man was pulled alive from rubble, 13 days after the quake struck.
The chances of finding more survivors now are practically zero, but aid organisations do not want people to forget Bam, says BBC correspondent in Geneva Imogen Foulkes.
Suffering 'just started'
The UN said it had raised $74m in aid for victims of the quake but said more money was needed.
"I have never met people having lost as many family members and as many relatives as the people of Bam. Some 30,000 people died in the course of a few hours," Jan Egeland, UN humanitarian co-ordinator told the BBC.
"A priority is shelter. People cannot continue to live in tents. We must get the water and sanitation systems working and we must provide people with an income," he said.
"The suffering of the Bam people has just started."
More than 40 countries sent aid to Iran soon after the quake, but aid agencies have warned that more help is needed for longer-term reconstruction.
The UN says Bam's survivors will still need international support in years to come.