Forty-nine people were killed when a flight from Newark to Buffalo crashed in Clarence Center, a suburb of Buffalo, in New York state. One person was also killed on the ground.
Residents described hearing an "eerie" noise and feeling the impact as the plane crashed, then seeing a large explosion.
Firefighters rushed to the scene minutes after the plane came down, but there were no survivors.
Witnesses said the house hit by the plane was completely demolished, and that the stench of burning fuel permeated the area.
Twelve other homes were evacuated around the crash site.
Clarence emergency control director Dave Bissonette said the crash could "have easily wiped out that entire neighbourhood".
It is not yet clear what caused the crash. Local weather reports said there was light snow and fog at the time.