Madeleine McCann disappeared from a holiday apartment in Praia da Luz, Portugal, on 3 May. A high-profile search ensued, under the full glare of the world's media.
Portuguese police teams carried out an intensive search of the countryside around the Algarve resort in the days after Madeleine went missing.
Kate and Gerry McCann with one of the many appeal posters which sprung up around Praia da Luz. The couple say they were at a nearby restaurant when Madeleine disappeared.
Appeals to find Madeleine have been made at many high-profile events, such as the FA Cup final between Chelsea and Manchester United at Wembley Stadium.
Kate and Gerry McCann were among those releasing balloons all over the world to mark 50 days since four-year-old Madeleine disappeared.
Kate and Gerry McCann say their Catholic faith has helped them cope. The Pope blessed a picture of Madeleine in an audience at the Vatican.
The McCanns made an appeal on BBC One's Crimewatch programme. Here they hold pyjamas similar to those Madeleine was wearing on 3 May.
Briton Robert Murat, who lives near the McCanns' holiday apartment, was for a long time the only official suspect. He has not been arrested or charged.
Kate McCann was constantly seen clutching a small pink toy called Cuddle Cat, a favourite of Madeleine's, in her appearances in public.
Kate and Gerry McCann were declared formal suspects in the investigation on 7 September. They deny any involvement.
Experts examined a picture of a girl taken by a Spanish tourist in Morocco, which it was thought could have been Madeleine.
However, journalists say she was not Madeleine but a five-year-old called Bushra, from the town of Zinat.
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