A pair of jeans James Dean wore in Giant and his white T-shirt from Rebel Without a Cause are estimated to fetch $15,000 (£8,000) in an online auction later this week.
Dean died aged just 24 when his Porsche Spyder collided with another vehicle on a California road. A fragment of the car is part of the auction organised by Heritage Auction Galleries.
A hat worn by Marlon Brando during the filming of the Godfather is accompanied by his annotated script of the iconic gangster movie.
More than 1,800 unashamedly trivial items are up for sale, from Fred Astaire's top hat to Charlie Chaplin's cane and Marilyn's matchbook case.
Music is well represented, from one of Elvis's first guitars to items belonging to Kurt Cobain and a reel to reel recording of Bob Dylan singing with a school friend.
The last such auction made over $1.6m (£848,000) but organisers believe this one "trumps them all". It also features a mannequin of Elaine from Seinfeld.