Pakistani protesters attacked fast-food outlets and other Western targets in Lahore venting their fury over Danish cartoons satirising the Prophet Muhammad.
Demonstrators damaged a McDonald's restaurant during Pakistan most violent protests so far over the caricatures.
Two demonstrators were shot dead and many more wounded, as crowds clashed with police.
In the capital, Islamabad, students stormed the area around Western embassies.
In the Pakistani city of Peshawar, the US and Danish leaders were satirised.
Demonstrators also condemned the Danish cartoons in the Kurdish Iraqi city of Irbil.
In Iran, protesters threw stones and petrol bombs at the UK embassy despite heavy police presence.
The largest Muslim nation, Indonesia, also contributed to Tuesday's anti-Danish protests.