Page last updated at 00:00 GMT, Tuesday, 5 January 2010

Cancer drugs 'treat' aggressive childhood brain tumours

Computer image of glioblastoma cells
Glioblastomas are aggressive and often fatal cancers of the brain

Aggressive childhood brain tumours could be treatable with a novel combination of two existing cancer drugs, a study suggests.

Researchers led by the Institute of Cancer Research (ICR) examined 90 tumours from children and found two new genetic abnormalities in nine of them.

They were then able to kill these abnormal tumours, in laboratory tests, by combining the two existing drugs.

But one expert says the findings remain "far off being applicable to patients".

In the UK, about 400 children are diagnosed with brain tumours every year.

The research, published in the journal Clinical Cancer Research, brought together scientists from the UK, France, Portugal, Brazil and America.

The abnormal tumours - known as glioblastomas, aggressive and often fatal cancers of the brain's glial cells - contained too many copies of the EGFR gene and mutations of the gene the scientists say have never before been found in children.

Cancers may look the same, but it is only when you get down to the genetic level that you can truly understand them and devise treatments
Dr Chris Jones

They tried to block the EGFR gene with a drug, erlotinib (Tarceva), used in clinical trials to treat adult glioblastomas, but identified a molecule specific to the children's cells - platelet-derived growth factor receptor (PGFR) - that was making it ineffective.

But when they combined erlotinib with a drug, imatinib (Glivec), they hoped would block the PGFR molecules, they killed a significant number of the cancer cells.

Dr Chris Jones, who led the research, said it proved "that cancers may look the same, but it is only when you get down to the genetic level that you can truly understand them and devise treatments".

Professor Geoff Pilkington, of the Brainstrust charity, said the research, though fascinating, was at too early a stage to turn into a treatment for patients.

"This sort of twin therapy is a good thing to consider for the future," he said.

Bur he added: "The cells of the brain seem to be unusually resistant to anything thrown at them."



Print Sponsor


SEE ALSO
NHS to get specialist cancer unit
18 Aug 09 |  Health
Brain radiotherapy affects mind
09 Aug 09 |  Health
Brain tumours 'forgotten cancer'
02 Jul 09 |  Health
Genetic clue to brain cancer risk
05 Jul 09 |  Health

RELATED INTERNET LINKS
The BBC is not responsible for the content of external internet sites


FEATURES, VIEWS, ANALYSIS
Has China's housing bubble burst?
How the world's oldest clove tree defied an empire
Why Royal Ballet principal Sergei Polunin quit

BBC navigation

BBC © 2013 The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.

Americas Africa Europe Middle East South Asia Asia Pacific