Page last updated at 23:53 GMT, Wednesday, 6 May 2009 00:53 UK

Trial drugs 'reverse' Alzheimer's

Pills
The drugs are licensed to treat certain types of cancer

US scientists say they have successfully reversed the effects of Alzheimer's with experimental drugs.

The drugs target and boost the function of a newly pinpointed gene involved in the brain's memory formation.

In mice, the treatment helped restore long-term memory and improve learning for new tasks, Nature reports.

The same drugs - HDAC inhibitors - are currently being tested to treat Huntington's disease and are on the market to treat some cancers.

They reshape the DNA scaffolding that supports and controls the expression of genes in the brain.

We need to do more research to investigate whether developing treatments that control this gene could benefit people with Alzheimer's
Rebecca Wood of the Alzheimer's Research Trust

The Alzheimer's gene the drugs act upon, histone deacetylase 2 (HDAC2), regulates the expression of a plethora of genes implicated in plasticity - the brain's ability to change in response to experience - and memory formation.

This findings build on the team's 2007 breakthrough in which mice with symptoms of Alzheimer's disease regained long-term memories and the ability to learn.

Lead researcher Professor Li-Huei Tsai explained: "It brings about long-lasting changes in how other genes are expressed, which is probably necessary to increase numbers of synapses and restructure neural circuits, thereby enhancing memory.

"To our knowledge, HDAC inhibitors have not been used to treat Alzheimer's disease or dementia.

"But now that we know that inhibiting HDAC2 has the potential to boost synaptic plasticity, synapse formation and memory formation.

"In the next step, we will develop new HDAC2-selective inhibitors and test their function for human diseases associated with memory impairment to treat neurodegenerative diseases."

Future hope

HDAC inhibitor treatment for humans with Alzheimer's disease is still a decade or more away, she said.

The chief executive of the Alzheimer's Research Trust, Rebecca Wood, said: "This is promising research which improves our understanding of memory loss in Alzheimer's.

"We need to do more research to investigate whether developing treatments that control this gene could benefit people with Alzheimer's.

"We desperately need to fund more research to head off a forecast doubling the UK population living with dementia."

Julie Williams, an expert in the genetics of Alzheimer's for the trust, said scientists were on the brink of finding a number of candidate genes that increase the risk of developing Alzheimer's.

"If we can find the triggers and causes then we can hopefully prevent them. That is the great ambition."



Print Sponsor


SEE ALSO
Alzheimer's drug 'halts' decline
29 Jul 08 |  Health
Dual action Alzheimer's drug hope
11 Jun 08 |  Health
Alzheimer's drugs remain limited
10 Aug 07 |  Health
Scientists 'reverse' memory loss
29 Apr 07 |  Health

RELATED BBC LINKS

RELATED INTERNET LINKS
The BBC is not responsible for the content of external internet sites


FEATURES, VIEWS, ANALYSIS
Has China's housing bubble burst?
How the world's oldest clove tree defied an empire
Why Royal Ballet principal Sergei Polunin quit

BBC navigation

BBC © 2013 The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.

Americas Africa Europe Middle East South Asia Asia Pacific