Page last updated at 06:29 GMT, Friday, 19 September 2008 07:29 UK

Baby paracetamol asthma concern

Baby being given liquid paracetamol
Paracetamol is an effective treatment for high fever

Use of paracetamol in babies increases the risk of developing asthma five years later, a study of more than 200,000 children suggests.

Those given the painkiller for fever in the first year of life had a 46% increased risk of asthma by the age of six or seven, The Lancet reported.

Researchers do not know if the drug directly increases asthma risk or another underlying factor is to blame.

Experts said parents should still use the drug for high temperatures.

Increasing use of paracetamol in children has coincided with rising cases of asthma over the past 50 years, the researchers said.

This underlines the importance of a current recommendation that paracetamol should not be used regularly in young children and should be reserved for times when they have a fever of 39C or more and are in obvious discomfort or pain
Professor Jeffrey Aronson

The latest study, carried out in 31 countries, is the largest to date looking at paracetamol use and childhood asthma.

Parents of children aged six and seven were asked questionnaires about symptoms of asthma, eczema and related allergic conditions in addition to details on paracetamol use for fever in the child's first year of life and the past 12 months.

The results also showed that higher doses and more regular use of the drug are associated with a greater risk of developing asthma.

Analysis of current use in 103,000 children showed those who had used paracetamol more than once a month in the past year had a three-fold increased risk of asthma compared with those who had not taken the drug in the past 12 months.

Use of paracetamol was also associated with more severe asthma symptoms.

And risk of eczema and hayfever was also increased.

Cause and effect

One explanation for the findings is that paracetamol may cause changes in the body that leave a child more vulnerable to inflammation and allergies.

Another is that the use of paracetamol in children may be a marker for something else which is causing increased rates of asthma, such as lifestyle issues or the underlying infection causing the fever, experts said.

Study leader Professor Richard Beasley from the University of Auckland said: "We stress the findings do not constitute a reason to stop using paracetamol in childhood.

"However the findings do lend support to the current guidelines of the World Health Organization, which recommend that paracetamol should be reserved for children with a high fever (38.5C or above)."

Professor Jeffrey Aronson, president of the British Pharmacological Society, said the dose relationship with paracetamol and asthma suggested there was a real association between the two.

"This confirms previous findings and underlines the importance of a current recommendation that paracetamol should not be used regularly in young children and should be reserved for times when they have a fever and are in obvious discomfort or pain."

Leanne Male, Asthma UK's assistant director of research, said: "Despite a great deal of research being carried out, we still don't know how important different lifestyle and genetic factors are in affecting the development of asthma.

"If we can establish the mechanisms behind how paracetamol might affect it, this could go some way towards helping to prevent the condition in the first place.

"At this stage however, the use of paracetamol should not be a concern for parents or carers who are worried about the development of asthma in their children."




SEE ALSO
Asthma risk from pregnancy nuts
15 Jul 08 |  Health
Asthma link to pregnancy stress
19 May 08 |  Health

RELATED INTERNET LINKS
The BBC is not responsible for the content of external internet sites


FEATURES, VIEWS, ANALYSIS
Has China's housing bubble burst?
How the world's oldest clove tree defied an empire
Why Royal Ballet principal Sergei Polunin quit

BBC iD

Sign in

BBC navigation

Copyright © 2015 BBC. The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.

Americas Africa Europe Middle East South Asia Asia Pacific