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Last Updated: Tuesday, 20 November 2007, 16:42 GMT
Q&A: Creating stem cells
Stem cell
Stem cells have huge potential
Stem cells are thought to hold huge potential for treating a wide range of disease and disability.

Scientists around the world are working on techniques to refine stem cell therapy.

The latest technique, nuclear reprogramming, promises to solve some of the trickiest practical and ethical issues.

What are stem cells?

Most adult cells in the body have a particular purpose which cannot be changed.

For instance, a liver cell is developed to perform specific functions, and cannot be transformed to suddenly take on the role of a heart cell.

Stem cells are different. They are still at an early stage of development, and retain the potential to turn into many different types of cell.

Why are they so useful?

When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialised function.

Scientists believe it should be possible to harness this ability to turn stem cells into a super "repair kit" for the body.

Theoretically, it should be possible to use stem cells to generate healthy tissue to replace that either damaged by trauma, or compromised by disease.

Among the conditions which scientists believe may eventually be treated by stem cell therapy are Parkinson's disease, Alzheimer's disease, heart disease, stroke, arthritis, diabetes, burns and spinal cord damage.

Stem cells may also provide a useful way to test the effects of experimental drugs.

It is also hoped that studying stem cells will provide vital clues about how the tissues of the body develop, and how disease takes hold.

Are there different types of stem cell?

Yes. Scientists believe the most useful stem cells come from the tissue of embyros.

This is because they are pluripotent - they have the ability to become virtually any type of cell within the body.

Stem cells are also found within adult organs. They have not taken on a final role, and have the potential to become any of the major specialised cell types within that organ.

Their role is to maintain the organ in a healthy state by repairing any damage it suffers.

It is thought their potential to become other types of cell is more limited than that of embryonic stem cells. But there is evidence that they are still relatively "plastic".

Can they be easily grown in the lab?

Large numbers of embryonic stem cells can be relatively easily grown in culture.

However, adult stem cells are rare in mature tissues and science is still working on ways to grow them in the lab in sufficient numbers.

This is an important distinction, as large numbers of cells are needed for stem cell replacement therapies.

Is the use of stem cells controversial?

Very. Campaigners are vehemently opposed to the use of embryonic stem cells.

These cells are typically taken from lab-created embryos that are just four or five days old, and are little more than a microscopic ball of cells.

However, opponents argue that all embryos, whether created in the lab or not, have the potential to go on to become a fully fledged human, and as such it is morally wrong to experiment on them.

They strongly advocate the use of stem cells from adult tissue.

What is nuclear reprogramming?

A new technique, in which cells isolated from skin tissue called fibroblasts are modified by inserting gene-controlling proteins.

This chemical cocktail causes the cells to be "reprogrammed" to take on the plastic quality of embryonic stem cells.

Why is the nuclear reprogramming an advance?

There are two big potential benefits. The current methods derive stem cells from from existing lab lines, but these cells are foreign to the body, and run the risk of rejection if used to repair or replace damaged or diseased tissue.

Nuclear reprogramming can potentially produce a supply of stem cells derived from a patient's own tissue - avoiding the issue of rejection of the cells.

Secondly, the technique does not require the creation of, or destruction of an embryo, and so is not ethically contentious.

Are there safety concerns?

Yes. Some researchers fear that it is possible that stem cell therapy could unwittingly pass viruses and other disease causing agents to people who receive cell transplants.

Some research has also raised the possibility that stem cells may turn cancerous.

Work also still needs to be done to refine the new technique. Similar results were achieved by two teams using a different combination of gene-controlling proteins.

In both cases the success rate in producing new stem cells was also low.



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