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Last Updated: Thursday, 7 December 2006, 13:39 GMT
'Facing up to my uncertain future'
Image of Ryan
Ryan Wilson was the worst affected of the six volunteers
A young trainee plumber left critically ill when a drug trial went dramatically wrong says he is determined to move on despite his uncertain future.

Ryan Wilson, 20, from London was the most seriously ill of the six men whose heads and bodies swelled up following injections of TGN1412 in March.

Mr Wilson had to have fingertips and all of his toes amputated and it is not clear what his future health will hold.

The drug may have left him prone to infections and cancer.

I do get depressed but I don't let it get to me
Ryan Wilson

Mr Wilson is determined to walk again, despite being in constant pain.

He said: "I just look forward to walking without crutches and being able to walk down the street looking relatively normal."

Uncertain future

But Ryan says he will never achieve his ambition of being a plumber.

He said: "I can't hold coins in my left hand, they just fall out, so I wouldn't be able to hold certain fittings.

"Even if I am in my house and touch something it hurts, so on a building site I am going to be in pain all the time."

He entered the trial that took place at a research unit run by Parexel at Northwick Park Hospital in London to pay for driving lessons.

He and five other volunteers were paid £2,000 to be given TGN1412, created by German pharmaceutical company TeGenero, by Parexel.

Ryan Wilson (BBC)
The drug caused nasty side effects

It was hoped that the drug would treat conditions such as rheumatoid arthritis and leukaemia, but the trial went disastrously wrong.

Ryan was the worst affected, suffering heart, liver and kidney failure, pneumonia, and septicaemia.

And his doctors are still unsure of the long-term damage that has been caused by TGN 1214.

Ryan says his uncertain future is depressing, but he remains optimistic.

He said: "I do get depressed but I don't let it get to me.

"I don't want to take antidepressants. I don't want to fight for my life because of one drug and then be dependent on another drug.

"It's always a case of mind over matter. I could spend the next however long I am around moping about it or try and get on with it as best as I can."


VIDEO AND AUDIO NEWS
Ryan Wilson talks about how he is still in pain



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