Europe South Asia Asia Pacific Americas Middle East Africa BBC Homepage World Service Education



Front Page

World

UK

UK Politics

Business

Sci/Tech

Health

Education

Sport

Entertainment

Talking Point
On Air
Feedback
Low Graphics
Help

Wednesday, November 11, 1998 Published at 13:14 GMT


Health

HIV vaccine fights off disease in monkeys

HIV vaccine works on monkeys

Scientists claim they have developed a vaccine that enables monkeys to fight off the HIV virus.

They plan to start testing it on humans next year.

Dr Alistair Ramsay, an immunologist at Australian National University, said: "It looks good so far. We just hope that it holds up when we get a chance to test it (on humans)."

Researchers in Canberra and Melbourne separately administered two vaccines, one to prime the immune system and another to boost it into action, before infecting four monkeys with the HIV virus.

The monkeys were initially infected but produced large numbers of T cells that attacked the virus, and cleared it from their system completely within weeks.

Four unvaccinated monkeys contracted the virus, which causes Aids in humans but not in monkeys.

The body's T cells are its first line of defence against infection, targeting and destroying foreign invaders.

According to the Journal of Virology, the researchers had to use two vaccines because neither was effective alone.

First they introduced a modified HIV gene into the monkeys' skin cells to stimulate their immune systems.

Several weeks later, they introduced a second dose of the HIV gene in a modified and harmless form to provoke a surge in the number of T cells.

When the macaque monkeys were then infected with HIV, the T cells multiplied even further and began to attack cells infected by the virus.

The World Health Organisation says up to 40 million people around the world are living with the Aids virus, with Africa the worst-affected continent but Asia also facing a pandemic.

The disease killed an estimated 2.3 million people last year.

Human trials


[ image: Macaque monkey]
Macaque monkey
The Australian team plans to use the vaccine in a therapeutic trial on HIV carriers in Sydney and Melbourne next year to see if the vaccine could help ward off AIDS.

Then it hopes to start overseas trials on non-infected humans, probably in southeast Asia.

The team hopes to win US funding, probably from the US-based International Aids Initiative, which helps speed the development of candidate vaccines.

Dr Ramsay said: "We would hope to be in clinical trials within two years - and we'd know within three to five years if it worked."

"The advantage of our system is it is very cheap and does not require refrigeration which can be a major difficulty in tropical countries."

Another researcher involved in the potential vaccine, Commonwealth Scientific and Industrial Research Organisation animal health specialist David Boyle, was more guarded.

"I'm quite cautious about HIV vaccines because there've been a lot of efforts so far and none has been successful," he said.

"Until you test it there's been no proof of the pudding."



Advanced options | Search tips




Back to top | BBC News Home | BBC Homepage | ©


Health Contents

Background Briefings
Medical notes

Relevant Stories

20 Oct 98 | Health
Aids masterplan 'has flaws'

14 Oct 98 | Health
Different HIV strains infect blood and semen

15 Sep 98 | Health
HIV to double in Asia by 2000





Internet Links


Aids sites

Terrence Higgins Trust

Cells alive


The BBC is not responsible for the content of external internet sites.




In this section

Disability in depth

Spotlight: Bristol inquiry

Antibiotics: A fading wonder

Mental health: An overview

Alternative medicine: A growth industry

The meningitis files

Long-term care: A special report

Aids up close

From cradle to grave

NHS reforms: A guide

NHS Performance 1999

From Special Report
NHS in crisis: Special report

British Medical Association conference '99

Royal College of Nursing conference '99