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Thursday, 24 January, 2002, 00:42 GMT
Scientists develop 'cloning alternative'
Human embryo research laboratory, BBC
Adult stem cells could be used to grow human tissue
An American scientist may have discovered a cell in adults that can turn into every single tissue in the body.

Until now, it was thought that only embryonic stem cells could do this.

Anti-abortion groups, who object to embryology research on ethical grounds, have welcomed the news which is reported in New Scientist magazine.


An option such as this which doesn't involve the deliberate production and destruction of life is much better

Tom Horwood, Catholic Church
Work is in its early stages but efforts are now being made to turn the adult cells into tissues such as muscle, cartilage and brain cells, which can be transplanted back into the patient.

The research has not been published in a scientific journal. However, it has been carried out by a highly respected team and received favourable reviews from those familiar with the work.

Ihor Lemischka of the US's Princeton University said: "The work is very exciting. They can differentiate into pretty much everything that an embryonic stem cell can differentiate into."

The cells were found in the bone marrow of adults by Catherine Verfaillie at the University of Minnesota.

Scientific potential

The cells, named multipotent adult progenitor cells (MAPCs), are said to have the same potential as embryonic stem cells (ESCs).

Irving Weissman of the US's Stanford University said: "It's very dramatic the kinds of observations Verfaillie is reporting. The findings, if reproducible, are remarkable."

Religious groups and "pro-family" organisations in the UK are among those who regularly raise concerns about the ethics of using embryo clones.

Tom Horwood from the Catholic Church said: "Over the last couple of years, researchers on both sides of the Atlantic have been looking at adult stem cells, so that's very much to be welcomed.

"An option such as this which doesn't involve the deliberate production and destruction of life is much better. What it needs is more support and finance."

The adult stem cells seem to grow indefinitely in culture, like ESCs.

Ethical debate

Some cell lines have been growing for almost two years and have kept their characteristics, with no signs of ageing, researchers claim.

The discovery of such "versatile adult stem cells" is likely to fan the debate about whether embryonic stem cell research is justified.

Anti-abortion groups argue the ethical concern is that the procedure involves creating an embryo for the sole purpose of providing a treatment for a disease.

They claim the adult stem cell development demonstrates the alternatives to therapeutic cloning. They believe these alternatives have been constantly underplayed by the scientific community.

Human embryo, BBC
Human embryo: Cloning raises ethical concerns
But scientists say that at this early stage of research, it is prudent to keep all options open. One expert is sceptical about the findings, questioning the nature of stem cells.

Verfaillie's team thinks MAPCs are rare cells present in the bone marrow that can be fished out through a series of enriching steps. But others think the selection process actually creates the MAPCs.

Neil Theise of New York University Medical School said: "I don't think there is a cell that is lurking there that can do this. I think Catherine has found a way to produce a cell that can behave this way."

Stem cell researchers say it is too early to tell whether the ultimate stem cell has been discovered and most believe research with embryonic stem cells must continue.

 WATCH/LISTEN
 ON THIS STORY
The BBC's Richard Black
"Progress has been painfully slow"
See also:

30 Jul 00 | Sci/Tech
Row over human cloning plans
03 Apr 00 | Sci/Tech
UK to 'approve therapeutic cloning'
01 Mar 00 | Sci/Tech
Call for stem cell banks
29 Feb 00 | Health
Diabetes reversed in the lab
05 Jan 00 | Sci/Tech
Lab grows frog eyes
17 Dec 99 | Sci/Tech
Stem cells top class of 1999
07 Nov 98 | Sci/Tech
Cell success has huge potential
06 Nov 98 | Sci/Tech
'Revolution in a dish'
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