Police in Italy say they have broken a major drug-trafficking ring - their second operation in two days.
More than 100 people were held over the last two days
Fifty people were arrested in co-ordinated raids in several cities in central Italy, police say.
Those detained are suspected of smuggling cocaine and heroin from Africa to several European countries.
On Wednesday up to 60 suspected drug-traffickers were held in southern Italy. The mafia is said to have been targeted in both operations.
Thursday's raids were carried out in and around Perugia, Naples, Pisa and the capital, Rome.
Most of those arrested were African.
Investigators believe couriers from Nigeria and Morocco - known as "mules" - swallow up to a kilogramme of drug-filled pellets at a time to move substances into Italy, Germany and the Netherlands.
The Calabria mafia, in particular, known as the 'Ndrangheta, has strong connections to powerful drug cartels in Africa and also South America, the BBC's Christian Fraser in Rome says.
He says that the Naples Mafia, known as the Camorra, has recently turned on itself.
After nine murders in the past two weeks some have called for the army to be sent to the city.